Rapid reconstruction of 2D plasma profiles from line-integral measurements is important in nuclear fusion. This paper introduces a physics-informed model architecture called Onion, that can enhance the performance of models and be adapted to various backbone networks. The model under Onion incorporates physical information by a multiplication process and applies the physics-informed loss function according to the principle of line integration. Prediction results demonstrate that the additional input of physical information improves the deep learning model's ability, leading to a reduction in the average relative error E_1 between the reconstruction profiles and the target profiles by approximately 0.84x10^(-2) on synthetic datasets and about 0.06x10^(-2) on experimental datasets. Furthermore, the implementation of the Softplus activation function in the final two fully connected layers improves model performance. This enhancement results in a reduction in the E_1 by approximately 1.06x10^(-2) on synthetic datasets and about 0.11x10^(-2) on experimental datasets. The incorporation of the physics-informed loss function has been shown to correct the model's predictions, bringing the back-projections closer to the actual inputs and reducing the errors associated with inversion algorithms. Besides, we have developed a synthetic data model to generate customized line-integral diagnostic datasets and have also collected soft x-ray diagnostic datasets from EAST and HL-2A. This study achieves reductions in reconstruction errors, and accelerates the development of surrogate models in fusion research.