Poisoning attacks are a primary threat to machine learning models, aiming to compromise their performance and reliability by manipulating training datasets. This paper introduces a novel attack - Outlier-Oriented Poisoning (OOP) attack, which manipulates labels of most distanced samples from the decision boundaries. The paper also investigates the adverse impact of such attacks on different machine learning algorithms within a multiclass classification scenario, analyzing their variance and correlation between different poisoning levels and performance degradation. To ascertain the severity of the OOP attack for different degrees (5% - 25%) of poisoning, we analyzed variance, accuracy, precision, recall, f1-score, and false positive rate for chosen ML models.Benchmarking our OOP attack, we have analyzed key characteristics of multiclass machine learning algorithms and their sensitivity to poisoning attacks. Our experimentation used three publicly available datasets: IRIS, MNIST, and ISIC. Our analysis shows that KNN and GNB are the most affected algorithms with a decrease in accuracy of 22.81% and 56.07% while increasing false positive rate to 17.14% and 40.45% for IRIS dataset with 15% poisoning. Further, Decision Trees and Random Forest are the most resilient algorithms with the least accuracy disruption of 12.28% and 17.52% with 15% poisoning of the IRIS dataset. We have also analyzed the correlation between number of dataset classes and the performance degradation of models. Our analysis highlighted that number of classes are inversely proportional to the performance degradation, specifically the decrease in accuracy of the models, which is normalized with increasing number of classes. Further, our analysis identified that imbalanced dataset distribution can aggravate the impact of poisoning for machine learning models