Hydrogen, the most abundant element in the universe, is crucial for understanding galaxy formation and evolution. The 21 cm neutral atomic hydrogen - HI spectral line maps the gas kinematics within galaxies, providing key insights into interactions, galactic structure, and star formation processes. With new radio instruments, the volume and complexity of data is increasing. To analyze and classify integrated HI spectral profiles in a efficient way, this work presents a framework that integrates Machine Learning techniques, combining unsupervised methods and CNNs. To this end, we apply our framework to a selected subsample of 318 spectral HI profiles of the CIG and 30.780 profiles from the Arecibo Legacy Fast ALFA Survey catalogue. Data pre-processing involved the Busyfit package and iterative fitting with polynomial, Gaussian, and double-Lorentzian models. Clustering methods, including K-means, spectral clustering, DBSCAN, and agglomerative clustering, were used for feature extraction and to bootstrap classification we applied K-NN, SVM, and Random Forest classifiers, optimizing accuracy with CNN. Additionally, we introduced a 2D model of the profiles to enhance classification by adding dimensionality to the data. Three 2D models were generated based on transformations and normalised versions to quantify the level of asymmetry. These methods were tested in a previous analytical classification study conducted by the Analysis of the Interstellar Medium in Isolated Galaxies group. This approach enhances classification accuracy and aims to establish a methodology that could be applied to data analysis in future surveys conducted with the Square Kilometre Array (SKA), currently under construction. All materials, code, and models have been made publicly available in an open-access repository, adhering to FAIR principles.