For decades, distributed systems have typically assumed that correct participants execute protocol-specified behavior with stable, externally defined, and deterministic semantics. Classical theory has extensively parameterized network timing, communication topologies, and failure domains, but this participant model has remained comparatively fixed. The integration of autonomous reasoning engines, stochastic model-driven agents, and policy-driven actors into cloud control planes, incident response systems, and financial infrastructure challenges the universality of this assumption. These agents often produce divergent reasoning paths, distinct operational traces, and heterogeneous internal representations while achieving semantically equivalent and correct outcomes. In this paper, we introduce Post-Deterministic Distributed Systems (PDDS) as a research and engineering model for coordinating heterogeneous environments where deterministic code, stochastic models, and autonomous agents coexist. We show that classical distributed computing models form a zero-ambiguity special case of this participant-general model. We do not argue that deterministic systems disappear; rather, deterministic execution can no longer serve as the universal participant assumption for autonomous infrastructure. Finally, we outline five architectural pillars of post-deterministic infrastructure: Protocol-Driven Development, Verifiable Agentic Infrastructure, Autonomous State Control Planes, Semantic Quorum Assurance, and Epistemic State Replication. Epistemic State Replication extends persistence and consistency models from data visibility to knowledge visibility, enabling agentic memory, Verifiable Semantic Rollback, and coherence across reasoning participants. We also define a taxonomy of failure classes that arise in this setting.