Genome Editing Consortium Workshop

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2024-11-07 · via News and Events Feed by Topic

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9:00 am – 9:15 am	Welcome & Opening Remarks Workshop Overview
9:15 - 10:00 am	Update from Federal Partners with Related Efforts FDA-CVM Regulatory Bioinformatics Analysis of Intentional Genomic Alterations (IGAs) in Animals Alexis Norris, Bioinformatician U.S. Food and Drug Administration, Center for Veterinary Medicine (FDA CVM) Update on the NIH Common Fund Somatic Cell Genome Editing (SCGE) Consortium Philip. J. Brooks, Co-Coordinator, SCGE program, Deputy Director, Division of Rare Diseases Research Innovation , NCATS, NIH Division of Rare Diseases Research Innovation , National Center for Advancing Translational Sciences, NIH How ARPA-H is leaning into NIST GE Consortium to support EMBODY performers Daria Fedyukina, Program Manager The Advanced Research Projects Agency for Health (ARPA-H)
10:00 – 10:40 am	Current NIST Genome Editing Consortium Activities Update and Discussion of Next Steps WG1 SPECIFICITY MEASUREMENTS: DNA- & CELL-BASED CONTROL MATERIALS & INTERLAB ANALYSES Updates on first interlab study and progress towards pilot engineered cell lines Samantha Maragh, Leader NIST Genome Editing Program Victor J. Weigman, VP, Computational Biology & Analytics Bioskryb Genomics, Inc. Ayah Shevchenko, Bioinformaticist NIST Genome Editing Program
10:40 am - 11:00 am	BREAK
11:00 am – 12:00 pm	Current NIST Genome Editing Consortium Activities Update and Discussion of Next Steps (continued) WG1-SUBGROUP: QUALITY OF GENOME EDITING COMPONENTS Subgroup Objective: Identify sources of variability and develop consensus approaches to qualifying off-target assays (including potential interlaboratory studies or control materials) Samantha Maragh, Leader NIST Genome Editing Program WG1- SUBGROUP: QUALIFICATION OF OFF-TARGET ASSAYS Subgroup Objective: Identify concepts/information, approaches/assays, and potential controls for assessing quality of genome editing components Puzhou Wang, Director, Research & Data Synthego Corporation Gavin Kurgan, Bioinformatics Applications and Market Development Manager Integrated DNA Technologies (IDT), Inc.
12:00 – 1:00 pm	BREAK
1:00 - 1:45 pm	Current NIST Genome Editing Consortium Activities Update and Discussion of Next Steps (continued) WG2 DATA & METADATA: GENOME EDITING METADATA SCHEMA NORM DEVELOPMENT UPDATES Sierra Miller, Bioinformaticist NIST Genome Editing Program Cole Lyman, Chief Executive Officer McKay Bowcut, Software Developer Trevor Martin, Software Developer Edilytics, Inc. WG3 Lexicon: ISO 5058 GENOME EDITING PT 1 VOCABULARY; ADDITIONAL TERMS TO CONSIDER Samantha Maragh, Leader NIST Genome Editing Program
1:45 - 2:30 pm	Breakout Topics OFF-TARGET GENOME EDITING: ANALYSIS, INTERPRETATION, & METADATA Samantha Maragh, Leader Patty Kiesler, Biologist Sierra Miller, Bioinformaticist Ayah Shevchenko, Bioinformaticist NIST Genome Editing Program Speaker TBD Integrated DNA Technologies (IDT), Inc.
2:30 - 2:45 pm	BREAK
2:45 - 3:45 pm	Breakout Topics (continued) MEASUREMENT CHALLENGES AND CONSIDERATIONS FOR EPIGENETIC EDITORS Keith Szulwach, Associate Director, Genome Sciences Ofer Yizhar-Barnea, Senior Scientist, Genome Sciences Scribe Therapeutics Inc. AI IN GENOME EDITING Grace Tiao, CEO Tim Poterba, CTO E9 Genomics CRISPR Genome Editing: Guide RNA Design using DNA Foundational Models Yaniv Shmueli, PhD, CTO & Co-founder Cassidy Bio
3:45 - 4:00 pm	BREAK
4:00 – 5:00 pm	Technology Talks (10 mins each) Precision Genotyping Tools for Gene Editing Analysis and Characterization Iván Hernández, CSO Countagen AB Precision Genome Editing Analysis with CRISPResso Cole Lyman, Chief Executive Officer Edilytics, Inc. Transposase-Based Tools for Genome Editing QC Workflows Joseph Mellor, PhD, Co-Founder and Chief Scientific Officer seqWell, Inc. Deep Reasoning with Biological Data: from Gene Editing Target Identification to Off-Target Prioritization and Interpretation Grace Tiao, CEO Tim Poterba, CTO E9 Genomics
5:00 – 5:15 pm	Re-Cap of Workshop & Adjourn

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