This paper proposes a novel and flexible security-aware semantic-driven integrated sensing and communication (ISAC) framework, namely security semantic ISAC (SS-ISAC). Inspired by the positive impact of the adversarial attack, a pair of pluggable encryption and decryption modules is designed in the proposed SS-ISAC framework. The encryption module is installed after the semantic transmitter, adopting a trainable adversarial residual network (ARN) to create the adversarial attack. Correspondingly, the decryption module before the semantic receiver utilizes another trainable ARN to mitigate the adversarial attack and noise. These two modules can be flexibly assembled considering the system security demands, without drastically modifying the hardware infrastructure. To ensure the sensing and communication (SAC) performance while preventing the eavesdropping threat, the above ARNs are jointly optimized by minimizing a carefully designed loss function that relates to the adversarial attack power, SAC performance, as well as the privacy leakage risk. Simulation results validate the effectiveness of the proposed SS-ISAC framework in terms of both SAC and eavesdropping prevention performance.