Artificial intelligence (AI) has become a transformative force across global societies, reshaping the ways we communicate, collaborate, and make decisions. Yet, as AI systems increasingly mediate interactions between humans, questions about the ability to take into account and understand culture, language, and context have taken center stage. This book explores these questions through a series of articles that try to assess AI's capacity to navigate cross-cultural, multilingual, and high-stakes policy environments, emphasizing human-centered approaches that balance technological innovation with social equity. It brings together six case studies from the First African Digital Humanism Summer School that took place in Kigali, Rwanda in July 2025.