The escalating climate crisis and ecosystem degradation demand intelligent, low-cost sensors capable of robust, long-term monitoring in real-world environments. Absolute dissolved oxygen (DO) concentration is a key parameter for predicting climate tipping points. Inexpensive optoelectronic sensors based on microstructured polymer films doped with phosphorescent dyes could be readily deployable; however, signal drift and marine biofouling remain major challenges. Here, we introduce a sensing paradigm that combines camera-based DO sensors with a visual transformer (ViT)-based physics-informed neural network (PINN) for high-fidelity sensing under biofouling conditions. Training and testing data were obtained from an algae-laden water tank over 14 days to capture accelerated biofouling. The ViT-PINN, which embeds the Stern-Volmer (SV) equation into the loss function, reduces mean average error (MAE) by 92% and 89% compared to classical statistical and ML approaches, achieving ~2 umol/L absolute error. A deep ensemble further quantifies predictive uncertainty, enabling self-diagnostic sensing.