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Policy Split: Incentivizing Dual-Mode Exploration in LLM Reinforcement with Dual-Mode Entropy Regularization METER: Evaluating Multi-Level Contextual Causal Reasoning in Large Language Models Think Before you Write: QA-Guided Reasoning for Character Descriptions in Books METRO: Towards Strategy Induction from Expert Dialogue Transcripts for Non-collaborative Dialogues Retrieval as Generation: A Unified Framework with Self-Triggered Information Planning Do LLMs Know Tool Irrelevance? Demystifying Structural Alignment Bias in Tool Invocations Enhancing Multimodal Large Language Models for Ancient Chinese Character Evolution Analysis via Glyph-Driven Fine-Tuning Exploring Knowledge Conflicts for Faithful LLM Reasoning: Benchmark and Method CocoaBench: Evaluating Unified Digital Agents in the Wild MathAgent: Adversarial Evolution of Constraint Graphs for Mathematical Reasoning Data Synthesis Efficient Training for Cross-lingual Speech Language Models Shared Emotion Geometry Across Small Language Models: A Cross-Architecture Study of Representation, Behavior, and Methodological Confounds A Systematic Analysis of the Impact of Persona Steering on LLM Capabilities Uncertainty-Aware Web-Conditioned Scientific Fact-Checking When Valid Signals Fail: Regime Boundaries Between LLM Features and RL Trading Policies When Verification Fails: How Compositionally Infeasible Claims Escape Rejection Mem$^2$Evolve: Towards Self-Evolving Agents via Co-Evolutionary Capability Expansion and Experience Distillation AOP-Smart: A RAG-Enhanced Large Language Model Framework for Adverse Outcome Pathway Analysis Advancing Polish Language Modeling through Tokenizer Optimization in the Bielik v3 7B and 11B Series TInR: Exploring Tool-Internalized Reasoning in Large Language Models Do BERT Embeddings Encode Narrative Dimensions? A Token-Level Probing Analysis of Time, Space, Causality, and Character in Fiction Generating Multiple-Choice Knowledge Questions with Interpretable Difficulty Estimation using Knowledge Graphs and Large Language Models Deep-Reporter: Deep Research for Grounded Multimodal Long-Form Generation Too Nice to Tell the Truth: Quantifying Agreeableness-Driven Sycophancy in Role-Playing Language Models Learning and Enforcing Context-Sensitive Control for LLMs Efficient Process Reward Modeling via Contrastive Mutual Information Computational Lesions in Multilingual Language Models Separate Shared and Language-specific Brain Alignment Bridging Linguistic Gaps: Cross-Lingual Mapping in Pre-Training and Dataset for Enhanced Multilingual LLM Performance Early Decisions Matter: Proximity Bias and Initial Trajectory Shaping in Non-Autoregressive Diffusion Language Models LLMs Should Incorporate Explicit Mechanisms for Human Empathy
Customizing Open Source LLMs for Quantitative Medication ...
Zhe Fei, Mehmet Yigit Turali, Shreyas Rajesh, Xinyang Dai, Huyen · 2025-10-24 · via cs.AI updates on arXiv.org

Harmonizing medication data across Electronic Health Record (EHR) systems is a persistent barrier to monitoring medications for opioid use disorder (MOUD). In heterogeneous EHR systems, key prescription attributes are scattered across differently formatted fields and freetext notes. We present a practical framework that customizes open source large language models (LLMs), including Llama, Qwen, Gemma, and MedGemma, to extract a unified set of MOUD prescription attributes (prescription date, drug name, duration, total quantity, daily quantity, and refills) from heterogeneous, site specific data and compute a standardized metric of medication coverage, \emph{MOUD days}, per patient. Our pipeline processes records directly in a fixed JSON schema, followed by lightweight normalization and cross-field consistency checks. We evaluate the system on prescription level EHR data from five clinics in a national OUD study (25{,}605 records from 1{,}257 patients), using a previously annotated benchmark of 10{,}369 records (776 patients) as the ground truth. Performance is reported as coverage (share of records with a valid, matchable output) and record-level exact-match accuracy. Larger models perform best overall: Qwen2.5-32B achieves \textbf{93.4\%} coverage with \textbf{93.0\%} exact-match accuracy across clinics, and MedGemma-27B attains \textbf{93.1\%}/\textbf{92.2\%}. A brief error review highlights three common issues and fixes: imputing missing dosage fields using within-drug norms, handling monthly/weekly injectables (e.g., Vivitrol) by setting duration from the documented schedule, and adding unit checks to prevent mass units (e.g., ``250 g'') from being misread as daily counts. By removing brittle, site-specific ETL and supporting local, privacy-preserving deployment, this approach enables consistent cross-site analyses of MOUD exposure, adherence, and retention in real-world settings.