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Policy Split: Incentivizing Dual-Mode Exploration in LLM Reinforcement with Dual-Mode Entropy Regularization METER: Evaluating Multi-Level Contextual Causal Reasoning in Large Language Models Think Before you Write: QA-Guided Reasoning for Character Descriptions in Books METRO: Towards Strategy Induction from Expert Dialogue Transcripts for Non-collaborative Dialogues Retrieval as Generation: A Unified Framework with Self-Triggered Information Planning Do LLMs Know Tool Irrelevance? Demystifying Structural Alignment Bias in Tool Invocations Enhancing Multimodal Large Language Models for Ancient Chinese Character Evolution Analysis via Glyph-Driven Fine-Tuning Exploring Knowledge Conflicts for Faithful LLM Reasoning: Benchmark and Method CocoaBench: Evaluating Unified Digital Agents in the Wild MathAgent: Adversarial Evolution of Constraint Graphs for Mathematical Reasoning Data Synthesis Efficient Training for Cross-lingual Speech Language Models Shared Emotion Geometry Across Small Language Models: A Cross-Architecture Study of Representation, Behavior, and Methodological Confounds A Systematic Analysis of the Impact of Persona Steering on LLM Capabilities Uncertainty-Aware Web-Conditioned Scientific Fact-Checking When Valid Signals Fail: Regime Boundaries Between LLM Features and RL Trading Policies When Verification Fails: How Compositionally Infeasible Claims Escape Rejection Mem$^2$Evolve: Towards Self-Evolving Agents via Co-Evolutionary Capability Expansion and Experience Distillation AOP-Smart: A RAG-Enhanced Large Language Model Framework for Adverse Outcome Pathway Analysis Advancing Polish Language Modeling through Tokenizer Optimization in the Bielik v3 7B and 11B Series TInR: Exploring Tool-Internalized Reasoning in Large Language Models Do BERT Embeddings Encode Narrative Dimensions? A Token-Level Probing Analysis of Time, Space, Causality, and Character in Fiction Generating Multiple-Choice Knowledge Questions with Interpretable Difficulty Estimation using Knowledge Graphs and Large Language Models Deep-Reporter: Deep Research for Grounded Multimodal Long-Form Generation Too Nice to Tell the Truth: Quantifying Agreeableness-Driven Sycophancy in Role-Playing Language Models Learning and Enforcing Context-Sensitive Control for LLMs Efficient Process Reward Modeling via Contrastive Mutual Information Computational Lesions in Multilingual Language Models Separate Shared and Language-specific Brain Alignment Bridging Linguistic Gaps: Cross-Lingual Mapping in Pre-Training and Dataset for Enhanced Multilingual LLM Performance Early Decisions Matter: Proximity Bias and Initial Trajectory Shaping in Non-Autoregressive Diffusion Language Models LLMs Should Incorporate Explicit Mechanisms for Human Empathy
RE-MCDF: Closed-Loop Multi-Expert LLM Reasoning for Knowl...
Shaowei Shen, Xiaohong Yang, Jie Yang, Lianfen Huang, Yongcai Zh · 2026-02-01 · via cs.AI updates on arXiv.org

Electronic medical records (EMRs), particularly in neurology, are inherently heterogeneous, sparse, and noisy, which poses significant challenges for large language models (LLMs) in clinical diagnosis. In such settings, single-agent systems are vulnerable to self-reinforcing errors, as their predictions lack independent validation and can drift toward spurious conclusions. Although recent multi-agent frameworks attempt to mitigate this issue through collaborative reasoning, their interactions are often shallow and loosely structured, failing to reflect the rigorous, evidence-driven processes used by clinical experts. More fundamentally, existing approaches largely ignore the rich logical dependencies among diseases, such as mutual exclusivity, pathological compatibility, and diagnostic confusion. This limitation prevents them from ruling out clinically implausible hypotheses, even when sufficient evidence is available. To overcome these, we propose RE-MCDF, a relation-enhanced multi-expert clinical diagnosis framework. RE-MCDF introduces a generation--verification--revision closed-loop architecture that integrates three complementary components: (i) a primary expert that generates candidate diagnoses and supporting evidence, (ii) a laboratory expert that dynamically prioritizes heterogeneous clinical indicators, and (iii) a multi-relation awareness and evaluation expert group that explicitly enforces inter-disease logical constraints. Guided by a medical knowledge graph (MKG), the first two experts adaptively reweight EMR evidence, while the expert group validates and corrects candidate diagnoses to ensure logical consistency. Extensive experiments on the neurology subset of CMEMR (NEEMRs) and on our curated dataset (XMEMRs) demonstrate that RE-MCDF consistently outperforms state-of-the-art baselines in complex diagnostic scenarios (https://github.com/shenshaowei/RE-MCDF).