Diffusion-based neural solvers for combinatorial optimization repeatedly re-evaluate dense edge/factor interactions, making inference expensive in wall-clock time and often memory-bound at scale. Inspired by the computational methodologies of many-body physics, we introduce LoRe, a training-free, inference-time drop-in wrapper that enforces per-step interaction-evaluation budgeting: at each iteration, it evaluates only a fixed fraction of interactions by dynamically routing computation to high-conflict or high-uncertainty interactions, instead of using a fixed sparsification (e.g., static kNN graphs or static masks). Under fully inclusive end-to-end wall-clock accounting, LoRe substantially improves scalability on the Maximum Independent Set (MIS) problem, extending feasible inference more than $3\times$ beyond the baseline's out-of-memory limit, delivering a $\sim 8\times$ speedup and a $\sim 12\times$ peak-memory reduction, with solution quality preserved in this regime. Demonstrating cross-task generality on the large-scale Traveling Salesperson Problem (TSP) and zero-shot robustness to topology shifts, LoRe achieves a $\sim 15\times$ speedup at $n=1000$ with a $44\times$ memory reduction and competitive tour quality.