Privacy-preserving technologies have introduced a paradigm shift that allows for realizable secure computing in real-world systems. The significant barrier to the practical adoption of these primitives is the computational and communication overhead that is incurred when applied at scale. In this paper, we present an overview of our efforts to bridge the gap between this overhead and practicality for privacy-preserving learning systems using multi-party computation (MPC), zero-knowledge proofs (ZKPs), and fully homomorphic encryption (FHE). Through meticulous hardware/software/algorithm co-design, we show progress towards enabling LLM-scale applications in privacy-preserving settings. We demonstrate the efficacy of our solutions in several contexts, including DNN IP ownership, ethical LLM usage enforcement, and transformer inference.