Large Language Models (LLMs) have revolutionized natural language processing tasks, but their deployment in datacenter environments faces significant challenges due to the massive memory requirements of key-value (KV) caches. During the autoregressive decoding process, KV caches consume substantial GPU memory, limiting batch sizes and overall system throughput. To address these challenges, we propose \textbf{CXL-SpecKV}, a novel disaggregated KV-cache architecture that leverages Compute Express Link (CXL) interconnects and FPGA accelerators to enable efficient speculative execution and memory disaggregation. Our approach introduces three key innovations: (i) a CXL-based memory disaggregation framework that offloads KV-caches to remote FPGA memory with low latency, (ii) a speculative KV-cache prefetching mechanism that predicts and preloads future tokens' cache entries, and (iii) an FPGA-accelerated KV-cache compression and decompression engine that reduces memory bandwidth requirements by up to 4$\times$. When evaluated on state-of-the-art LLM models, CXL-SpecKV achieves up to 3.2$\times$ higher throughput compared to GPU-only baselines, while reducing memory costs by 2.8$\times$ and maintaining accuracy. Our system demonstrates that intelligent memory disaggregation combined with speculative execution can effectively address the memory wall challenge in large-scale LLM serving. Our code implementation has been open-sourced at https://github.com/FastLM/CXL-SpecKV.