The widespread adoption of open-source software (OSS) necessitates the mitigation of vulnerability risks. Most vulnerability detection (VD) methods are limited by inadequate contextual understanding, restrictive single-round interactions, and coarse-grained evaluations, resulting in undesired model performance and biased evaluation results. To address these challenges, we propose MAVUL, a novel multi-agent VD system that integrates contextual reasoning and interactive refinement. Specifically, a vulnerability analyst agent is designed to flexibly leverage tool-using capabilities and contextual reasoning to achieve cross-procedural code understanding and effectively mine vulnerability patterns. Through iterative feedback and refined decision-making within cross-role agent interactions, the system achieves reliable reasoning and vulnerability prediction. Furthermore, MAVUL introduces multi-dimensional ground truth information for fine-grained evaluation, thereby enhancing evaluation accuracy and reliability. Extensive experiments conducted on a pairwise vulnerability dataset demonstrate MAVUL's superior performance. Our findings indicate that MAVUL significantly outperforms existing multi-agent systems with over 62% higher pairwise accuracy and single-agent systems with over 600% higher average performance. The system's effectiveness is markedly improved with increased communication rounds between the vulnerability analyst agent and the security architect agent, underscoring the importance of contextual reasoning in tracing vulnerability flows and the crucial feedback role. Additionally, the integrated evaluation agent serves as a critical, unbiased judge, ensuring a more accurate and reliable estimation of the system's real-world applicability by preventing misleading binary comparisons.