Despite the impressive generative capabilities of text-to-image (T2I) diffusion models, they remain vulnerable to generating inappropriate content, especially when confronted with implicit sexual prompts. Unlike explicit harmful prompts, these subtle cues, often disguised as seemingly benign terms, can unexpectedly trigger sexual content due to underlying model biases, raising significant ethical concerns. However, existing detection methods are primarily designed to identify explicit sexual content and therefore struggle to detect these implicit cues. Fine-tuning approaches, while effective to some extent, risk degrading the model's generative quality, creating an undesirable trade-off. To address this, we propose NDM, the first noise-driven detection and mitigation framework, which could detect and mitigate implicit malicious intention in T2I generation while preserving the model's original generative capabilities. Specifically, we introduce two key innovations: first, we leverage the separability of early-stage predicted noise to develop a noise-based detection method that could identify malicious content with high accuracy and efficiency; second, we propose a noise-enhanced adaptive negative guidance mechanism that could optimize the initial noise by suppressing the prominent region's attention, thereby enhancing the effectiveness of adaptive negative guidance for sexual mitigation. Experimentally, we validate NDM on both natural and adversarial datasets, demonstrating its superior performance over existing SOTA methods, including SLD, UCE, and RECE, etc. Code and resources are available at https://github.com/lorraine021/NDM.