We construct a 2-categorical extension of the relative entropy functor of Baez and Fritz, and show that our construction is functorial with respect to vertical morphisms. Moreover, we show such a `2-relative entropy' satisfies natural 2-categorial analogues of convex linearity, vanishing under optimal hypotheses, and lower semicontinuity. While relative entropy is a relative measure of information between probability distributions, we view our construction as a relative measure of information between channels.