This paper investigates goal-oriented communication for remote estimation of multiple Markov sources in resource-constrained networks. An agent decides the updating times of the sources and transmits the packet to a remote destination over an unreliable channel with delay. The destination is tasked with source reconstruction for actuation. We utilize the metric \textit{cost of actuation error} (CAE) to capture the state-dependent actuation costs. We aim for a sampling policy that minimizes the long-term average CAE subject to an average resource constraint. We formulate this problem as an average-cost constrained Markov Decision Process (CMDP) and relax it into an unconstrained problem by utilizing \textit{Lyapunov drift} techniques. Then, we propose a low-complexity \textit{drift-plus-penalty} (DPP) policy for systems with known source/channel statistics and a Lyapunov optimization-based deep reinforcement learning (LO-DRL) policy for unknown environments. Our policies significantly reduce the number of uninformative transmissions by exploiting the timing of the important information.