Fisher's Method of Maximum Likelihood is shown to be a procedure for the construction of likelihood intervals or regions, instead of a procedure of point estimation. Based on Fisher's articles and books it is justified that by estimation Fisher meant the construction of likelihood intervals or regions from appropriate likelihood function and that an estimate is a statistic, that is, a function from a sample space to a parameter space such that the likelihood function obtained from the sampling distribution of the statistic at the observed value of the statistic is used to construct likelihood intervals or regions. Thus Problem of Estimation is how to choose the 'best' estimate. Fisher's solution for the problem of estimation is Maximum Likelihood Estimate (MLE). Fisher's Theory of Statistical Estimation is a chain of ideas used to justify MLE as the solution of the problem of estimation. The construction of confidence intervals by the delta method from the asymptotic normal distribution of MLE is based on Fisher's ideas, but is against his 'logic of statistical inference'. Instead the construction of confidence intervals from the profile likelihood function of a given interest function of the parameter vector is considered as a solution more in line with Fisher's 'ideology'. A new method of calculation of profile likelihood-based confidence intervals for general smooth interest functions in general statistical models is considered.