We present a framework for speeding up the time it takes to sample from discrete distributions $μ$ defined over subsets of size $k$ of a ground set of $n$ elements, in the regime $k\ll n$. We show that having estimates of marginals $\mathbb{P}_{S\sim μ}[i\in S]$, the task of sampling from $μ$ can be reduced to sampling from distributions $ν$ supported on size $k$ subsets of a ground set of only $n^{1-α}\cdot \operatorname{poly}(k)$ elements. Here, $1/α\in [1, k]$ is the parameter of entropic independence for $μ$. Further, the sparsified distributions $ν$ are obtained by applying a sparse (mostly $0$) external field to $μ$, an operation that often retains algorithmic tractability of sampling from $ν$. This phenomenon, which we dub domain sparsification, allows us to pay a one-time cost of estimating the marginals of $μ$, and in return reduce the amortized cost needed to produce many samples from the distribution $μ$, as is often needed in upstream tasks such as counting and inference. For a wide range of distributions where $α=Ω(1)$, our result reduces the domain size, and as a corollary, the cost-per-sample, by a $\operatorname{poly}(n)$ factor. Examples include monomers in a monomer-dimer system, non-symmetric determinantal point processes, and partition-constrained Strongly Rayleigh measures. Our work significantly extends the reach of prior work of Anari and Dereziński who obtained domain sparsification for distributions with a log-concave generating polynomial (corresponding to $α=1$). As a corollary of our new analysis techniques, we also obtain a less stringent requirement on the accuracy of marginal estimates even for the case of log-concave polynomials; roughly speaking, we show that constant-factor approximation is enough for domain sparsification, improving over $O(1/k)$ relative error established in prior work.