An antimagic labeling of a directed graph $D$ with $n$ vertices and $m$ arcs is a bijection from the set of arcs of $D$ to the integers $\{1, \cdots, m\}$ such that all $n$ oriented vertex sums are pairwise distinct, where an oriented vertex sum is the sum of labels of all arcs entering that vertex minus the sum of labels of all arcs leaving it. A graph $G$ has an antimagic orientation if it has an orientation which admits an antimagic labeling. Hefetz, M{ü}tze, and Schwartz conjectured that every connected graph admits an antimagic orientation. In this paper, we show that every bipartite graph without both isolated and degree 2 vertices admits an antimagic orientation and every graph $G$ with $δ(G)\ge 33$ admits an antimagic orientation. Our proof relies on a newly developed structural property of bipartite graphs, which might be of independent interest.