We generalize the well-known "12" and "24" Theorems for reflexive polytopes of dimension 2 and 3 to any smooth reflexive polytope. Our methods apply to a wider category of objects, here called reflexive GKM graphs, that are associated with certain monotone symplectic manifolds which do not necessarily admit a toric action. As an application, we provide bounds on the Betti numbers for certain monotone Hamiltonian spaces which depend on the minimal Chern number of the manifold.