We present a new algorithmic approach that can be used to determine whether a given quadruple $(f_0,f_1,f_2,f_3)$ is the f-vector of any convex 4-dimensional polytope. By implementing this approach, we classify the f-vectors of 4-polytopes in the range $f_0+f_3\le22$. In particular, we thus prove that there are f-vectors of cellular 3-spheres with the intersection property that are not f-vectors of any convex 4-polytopes, thus answering a question that may be traced back to the works of Steinitz (1906/1922). In the range $f_0+f_3\le22$, there are exactly three such f-vectors with $f_0\le f_3$, namely $(10,32,33,11)$, $(10,33,35,12)$, and $(11,35,35,11)$.