A long-standing conjecture asserts that there exists a constant $c>0$ such that every graph of order $n$ without isolated vertices contains an induced subgraph of order at least $cn$ with all degrees odd. Scott (1992) proved that every graph $G$ has an induced subgraph of order at least $|V(G)|/(2χ(G))$ with all degrees odd, where $χ(G)$ is the chromatic number of $G$, this implies the conjecture for graphs with { bounded} chromatic number. But the factor $1/(2χ(G))$ seems to be not best possible, for example, Radcliffe and Scott (1995) proved $c=\frac 23$ for trees, Berman, Wang and Wargo (1997) showed that $c=\frac 25$ for graphs with maximum degree $3$, so it is interesting to determine the exact value of $c$ for special family of graphs. In this paper, we further confirm the conjecture for graphs with treewidth at most 2 with $c=\frac{2}{5}$, and the bound is best possible.