If $X=(V(X),E(X))$ and $Y=(V(Y),E(Y))$ are $n$-vertex graphs, then their friends-and-strangers graph $\mathsf{FS}(X,Y)$ is the graph whose vertices are the bijections from $V(X)$ to $V(Y)$ in which two bijections $σ$ and $σ'$ are adjacent if and only if there is an edge $\{a,b\}\in E(X)$ such that $\{σ(a),σ(b)\}\in E(Y)$ and $σ'=σ\circ (a\,\,b)$, where $(a\,\,b)$ is the permutation of $V(X)$ that swaps $a$ and $b$. We prove general theorems that provide necessary and/or sufficient conditions for $\mathsf{FS}(X,Y)$ to be connected. As a corollary, we obtain a complete characterization of the graphs $Y$ such that $\mathsf{FS}(\mathsf{Dand}_{k,n},Y)$ is connected, where $\mathsf{Dand}_{k,n}$ is a dandelion graph; this substantially generalizes a theorem of the first author and Kravitz in the case $k=3$. For specific choices of $Y$, we characterize the spider graphs $X$ such that $\mathsf{FS}(X,Y)$ is connected. In a different vein, we study the cycle spaces of friends-and-strangers graphs. Naatz proved that if $X$ is a path graph, then the cycle space of $\mathsf{FS}(X,Y)$ is spanned by $4$-cycles and $6$-cycles; we show that the same statement holds when $X$ is a cycle and $Y$ has domination number at least $3$. When $X$ is a cycle and $Y$ has domination number at least $2$, our proof sheds light on how walks in $\mathsf{FS}(X,Y)$ behave under certain Coxeter moves.