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Adaptive multi-fidelity optimization with fast learning rates Enhancing AI and Dynamical Subseasonal Forecasts with Probabilistic Bias Correction Sample Complexity Bounds for Stochastic Shortest Path with a Generative Model The Harder Path: Last Iterate Convergence for Uncoupled Learning in Zero-Sum Games with Bandit Feedback Stylistic-STORM (ST-STORM) : Perceiving the Semantic Nature of Appearance Collective Kernel EFT for Pre-activation ResNets PRIM-cipal components analysis One-Shot Generative Flows: Existence and Obstructions Structural interpretability in SVMs with truncated orthogonal polynomial kernels Amortized Optimal Transport from Sliced Potentials MinShap: A Modified Shapley Value Approach for Feature Selection Unsupervised feature selection using Bayesian Tucker decomposition Multi-User mmWave Beam and Rate Adaptation via Combinatorial Satisficing Bandits Best of both worlds: Stochastic & adversarial best-arm identification Scalable Model-Based Clustering with Sequential Monte Carlo Expert-Guided Class-Conditional Goodness-of-Fit Scores for Interpretable Classification with Informative Missingness: An Application to Seismic Monitoring Lightweight Geometric Adaptation for Training Physics-Informed Neural Networks Gating Enables Curvature: A Geometric Expressivity Gap in Attention Zeroth-Order Optimization at the Edge of Stability Differentially Private Conformal Prediction CLion: Efficient Cautious Lion Optimizer with Enhanced Generalization Generative Augmented Inference Improving Machine Learning Performance with Synthetic Augmentation PAC-MCTS: Bias-Aware Pruning for Robust LLM-Guided Search and Planning Path-Sampled Integrated Gradients Heat and Matérn Kernels on Matchings Doubly Outlier-Robust Online Infinite Hidden Markov Model Momentum Further Constrains Sharpness at the Edge of Stochastic Stability Multistage Conditional Compositional Optimization BOAT: Navigating the Sea of In Silico Predictors for Antibody Design via Multi-Objective Bayesian Optimization
Time-dependent Probabilistic Generative Models for Diseas...
Onintze Zaballa, Aritz Pérez, Elisa Gómez-Inhiesto, Teresa Acait · 2023-11-16 · via stat.ML updates on arXiv.org

Electronic health records contain valuable information for monitoring patients' health trajectories over time. Disease progression models have been developed to understand the underlying patterns and dynamics of diseases using these data as sequences. However, analyzing temporal data from EHRs is challenging due to the variability and irregularities present in medical records. We propose a Markovian generative model of treatments developed to (i) model the irregular time intervals between medical events; (ii) classify treatments into subtypes based on the patient sequence of medical events and the time intervals between them; and (iii) segment treatments into subsequences of disease progression patterns. We assume that sequences have an associated structure of latent variables: a latent class representing the different subtypes of treatments; and a set of latent stages indicating the phase of progression of the treatments. We use the Expectation-Maximization algorithm to learn the model, which is efficiently solved with a dynamic programming-based method. Various parametric models have been employed to model the time intervals between medical events during the learning process, including the geometric, exponential, and Weibull distributions. The results demonstrate the effectiveness of our model in recovering the underlying model from data and accurately modeling the irregular time intervals between medical actions.