Machine Learning (ML) is a powerful tool for material science applications. Artificial Neural Network (ANN) is a machine learning technique that can provide high prediction accuracy. This study aimed to develop an ANN model to predict the cake moisture of the pressure filtration process of zinc production. The cake moisture was influenced by seven parameters: temperature (35 and 65 Celsius), solid concentration (0.2 and 0.38 g/L), pH (2, 3.5, and 5), air-blow time (2, 10, and 15 min), cake thickness (14, 20, 26, and 34 mm), pressure, and filtration time. The study conducted 288 tests using two types of fabrics: polypropylene (S1) and polyester (S2). The ANN model was evaluated by the Coefficient of determination (R2), the Mean Square Error (MSE), and the Mean Absolute Error (MAE) metrics for both datasets. The results showed R2 values of 0.88 and 0.83, MSE values of 6.243x10-07 and 1.086x10-06, and MAE values of 0.00056 and 0.00088 for S1 and S2, respectively. These results indicated that the ANN model could predict the cake moisture of pressure filtration in the zinc leaching process with high accuracy.