We study the fundamental problems of agnostically learning halfspaces and ReLUs under Gaussian marginals. In the former problem, given labeled examples $(\mathbf{x}, y)$ from an unknown distribution on $\mathbb{R}^d \times \{ \pm 1\}$, whose marginal distribution on $\mathbf{x}$ is the standard Gaussian and the labels $y$ can be arbitrary, the goal is to output a hypothesis with 0-1 loss $\mathrm{OPT}+ε$, where $\mathrm{OPT}$ is the 0-1 loss of the best-fitting halfspace. In the latter problem, given labeled examples $(\mathbf{x}, y)$ from an unknown distribution on $\mathbb{R}^d \times \mathbb{R}$, whose marginal distribution on $\mathbf{x}$ is the standard Gaussian and the labels $y$ can be arbitrary, the goal is to output a hypothesis with square loss $\mathrm{OPT}+ε$, where $\mathrm{OPT}$ is the square loss of the best-fitting ReLU. We prove Statistical Query (SQ) lower bounds of $d^{\mathrm{poly}(1/ε)}$ for both of these problems. Our SQ lower bounds provide strong evidence that current upper bounds for these tasks are essentially best possible.