Background: Social determinants of health (SDoH) play a crucial role in influencing health outcomes, accounting for nearly 50% of modifiable health factors and bringing to light critical disparities among disadvantaged groups. Despite the significant impact of SDoH, existing data resources often fall short in terms of comprehensiveness, integration, and usability. Methods: To address these gaps, we developed an extensive Exposome database and a corresponding web application, aimed at enhancing data usability and integration with electronic health record (EHR) to foster personalized and informed healthcare. We created a robust database consisting of a wide array of SDoH indicators and an automated linkage tool designed to facilitate effortless integration with EHR. We emphasized a user-friendly interface to cater to researchers, clinicians, and public health professionals. Results: The resultant Exposome database and web application offer an extensive data catalog with enhanced usability features. The automated linkage tool has demonstrated efficiency in integrating SDoH data with EHRs, significantly improving data accessibility. Initial deployment has confirmed scalability and robust spatial data relationships, facilitating precise and contextually relevant healthcare insights. Conclusion: The development of an advanced Exposome database and linkage tool marks a significant step toward enhancing the accessibility and usability of SDoH data. By centralizing and integrating comprehensive SDoH indicators with EHRs, this tool empowers a wide range of users to access high-quality, standardized data. This resource will have a lasting impact on personalized healthcare and equitable health landscape.