Our main goal in this paper is to quantitatively compare the performance of classical methods to XGBoost and convolutional neural networks in a parameter estimation problem for epidemic spread. As we use flexible two-layer random graphs as the underlying network, we can also study how much the structure of the graphs in the training set and the test set can differ while to get a reasonably good estimate. In addition, we also examine whether additional information (such as the average degree of infected vertices) can help improving the results, compared to the case when we only know the time series consisting of the number of susceptible and infected individuals. Our simulation results also show which methods are most accurate in the different phases of the epidemic.