As data are increasingly modeled as graphs for expressing complex relationships, the tree pattern query on graph-structured data becomes an important type of queries in real-world applications. Most practical query languages, such as XQuery and SPARQL, support logical expressions using logical-AND/OR/NOT operators to define structural constraints of tree patterns. In this paper, (1) we propose generalized tree pattern queries (GTPQs) over graph-structured data, which fully support propositional logic of structural constraints. (2) We make a thorough study of fundamental problems including satisfiability, containment and minimization, and analyze the computational complexity and the decision procedures of these problems. (3) We propose a compact graph representation of intermediate results and a pruning approach to reduce the size of intermediate results and the number of join operations -- two factors that often impair the efficiency of traditional algorithms for evaluating tree pattern queries. (4) We present an efficient algorithm for evaluating GTPQs using 3-hop as the underlying reachability index. (5) Experiments on both real-life and synthetic data sets demonstrate the effectiveness and efficiency of our algorithm, from several times to orders of magnitude faster than state-of-the-art algorithms in terms of evaluation time, even for traditional tree pattern queries with only conjunctive operations.