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Arizona Diamondbacks vs. St. Louis Cardinals prediction, ...
Keagan Smith · 2026-06-25 · via DraftKings Network

Keagan Smith gives you a preview, prediction and pick for today’s game between the Arizona Diamondbacks and St. Louis Cardinals on Wednesday’s MLB slate.

On Wednesday night, two scrappy clubs square off as the Arizona Diamondbacks play the third leg of this series against the St. Louis Cardinals. Both sides are above .500 and vying to move up in their respective division standings amidst a crowded NL Wild Card picture. First pitch is scheduled for 7:45 p.m. ET.

Here’s a betting prediction and pick for this Diamondbacks vs. Cardinals matchup courtesy of MLB odds and lines on DraftKings Sportsbook.

Diamondbacks vs. Cardinals prediction, preview

Arizona Diamondbacks

The D-Backs aren’t likely to make it to the top of the NL West by any means, at least as long as the L.A. Dodgers are dominating. They are 40-39 though and seem to find ways to float around .500, even if the run differential this year is an uninspiring -25. The club averages 4.27 runs per game and is marginally better on the road with 4.36, while the overall OPS of .692 ranks 27th in the MLB. That’s due to a .238/.308/.383 slash line, with the OBP and SLG both in the sport’s bottom five. Tonight they’ll face a left-hander, which could provide a major boost thanks to a .268/.328/.434 line for a .761 OPS in the split. Plus, 21 of their 69 homers have come off southpaws and an ISO of .165 against them is far better than the .146 overall mark. Arizona does excel at limiting strikeouts with a 16.6% K% that ranks third best, with an 8.5% BB% as well.

For Arizona, rookie LHP Mitch Bratt throws his 12th start tonight with a 1-1 record. He brings a 2.84 ERA with an 0.95 WHIP and 42 strikeouts in 44.1 IP, an excellent start to his MLB career. He’s backed by a bullpen that ranks 17th in ERA at 4.27 with a 1.26 WHIP and 11.7% K-BB%.

St. Louis Cardinals

The Cardinals find themselves ahead of schedule and in a somewhat similar position, chasing the Milwaukee Brewers in the NL Central. At 42-35, they’re achieving at a higher level than expected and have a +4 run differential as well. St. Louis’ .726 OPS ranks 13th on a slash line of .249/.328/.399, averaging 4.61 runs a night. It’s worth noting that the club falls to just 3.95 runs per game at home, though. The Redbirds bring a .150 ISO with 87 dingers, with 22 coming against left-handers. They face one tonight, slashing .248/.328/.380 for a downturn of a .707 OPS in the split. They’re also excellent at keeping strikeouts down with a K% of 20.3% that ranks fourth best, plus a BB% of 8.9%. There’s plenty of upside with this lineup, it’s just a matter of whether they can find it on a consistent basis at home.

LHP Matthew Liberatore starts tonight with a 3-4 record. He has a 5.23 ERA, a 1.56 WHIP and 67 strikeouts across 72.1 IP. The Cardinals’ bullpen sits 19th in ERA at 4.38 with a 1.37 WHIP and a 10.0% K-BB%, too.

Diamondbacks vs. Cardinals pick, best bet

DraftKings Sportsbook lists the Cardinals as -119 home favorites on the Moneyline tonight. The Diamondbacks are -102 underdogs to win outright. The run total sits at nine combined runs this evening.

Best Bet: Matthew Liberatore over 9.5 H + BB + ER allowed (-128)

This pitcher prop checks out in my book tonight for two reasons. First up, the Snakes are pretty darn good at the plate against southpaws. Their .759 OPS in that split ranks third among all MLB clubs with top-six marks in both OBP and SLG. They also have a .165 ISO that sits eighth, so they’re legitimately really good when staring down lefties. Unfortunately for Matthew Liberatore, he’s not been a very good one this year. Over his last six starts, he’s allowed more than 9.5 combined hits, walks and earned runs five times. That includes three seven-hit games and four outings of four or more earned runs. That’s all while pitching 5.1 or fewer innings in every one of those starts. He could get chased quickly, but not before the damage is done.