Open-Ended object Detection (OED) is a novel and challenging task that detects objects and generates their category names in a free-form manner, without requiring additional vocabularies during inference. However, the existing OED models, such as GenerateU, require large-scale datasets for training, suffer from slow convergence, and exhibit limited performance. To address these issues, we present a novel and efficient Open-Det framework, consisting of four collaborative parts. Specifically, Open-Det accelerates model training in both the bounding box and object name generation process by reconstructing the Object Detector and the Object Name Generator. To bridge the semantic gap between Vision and Language modalities, we propose a Vision-Language Aligner with V-to-L and L-to-V alignment mechanisms, incorporating with the Prompts Distiller to transfer knowledge from the VLM into VL-prompts, enabling accurate object name generation for the LLM. In addition, we design a Masked Alignment Loss to eliminate contradictory supervision and introduce a Joint Loss to enhance classification, resulting in more efficient training. Compared to GenerateU, Open-Det, using only 1.5% of the training data (0.077M vs. 5.077M), 20.8% of the training epochs (31 vs. 149), and fewer GPU resources (4 V100 vs. 16 A100), achieves even higher performance (+1.0% in APr). The source codes are available at: https://github.com/Med-Process/Open-Det.