Serious games are widely used for learning and training across domains such as healthcare, defense, and education. Persistent challenges remain, however, including static scenario design, authoring bottlenecks, limited learner modeling, and difficulty implementing meaningful real-time instructional adaptation. Recent advances in artificial intelligence (AI) introduce novel capabilities such as dynamic scenario variation, contextual feedback, adaptive pacing, and learner-state modeling that may help address some of these limitations. At the same time, integrating AI into serious games raises important questions related to validity, transparency, system control, and learner trust. This chapter examines how contemporary AI approaches may support real-time instructional adaptation in serious games. It distinguishes between instructional intelligence, defined as a system's capacity to infer learner knowledge and reason about pedagogically appropriate responses, and adaptivity, defined as the ability to modify instructional actions during interaction. A historical synthesis of adaptive learning systems is presented, tracing developments from early computer-assisted instruction through intelligent tutoring systems (ITS), dynamic difficulty adjustment (DDA), authoring platforms, learning analytics, and recent AI-enabled architectures. Building on this perspective, the chapter discusses how large language models (LLMs), reinforcement learning (RL), and agent-based architectures may contribute to more integrated forms of intelligence and adaptivity in serious games. It also highlights practical and research challenges associated with AI-enabled systems, including explainability, validation, computational cost, and the limited empirical evidence regarding long-term learning outcomes in AI-enabled serious games.