The rapid advancement of Large Language Model (LLM)-based Multi-Agent Systems (MAS) has introduced significant security vulnerabilities, where malicious influence can propagate virally through inter-agent communication. Conventional safeguards often rely on a binary paradigm that strictly distinguishes between benign and attack agents, failing to account for infected agents i.e., benign entities converted by attack agents. In this paper, we propose Infection-Aware Guard, INFA-Guard, a novel defense framework that explicitly identifies and addresses infected agents as a distinct threat category. By leveraging infection-aware detection and topological constraints, INFA-Guard accurately localizes attack sources and infected ranges. During remediation, INFA-Guard replaces attackers and rehabilitates infected ones, avoiding malicious propagation while preserving topological integrity. Extensive experiments demonstrate that INFA-Guard achieves state-of-the-art performance, reducing the Attack Success Rate (ASR) by an average of 33%, while exhibiting cross-model robustness, superior topological generalization, and high cost-effectiveness.