The last eight American passengers who endured 42 days in a specialized hospital quarantine unit after exposure to an unusual hantavirus outbreak on a cruise ship that killed three people have left the Nebraska facility.

U.S. Department of Health and Human Services officials on Monday (June 22, 2026) confirmed the end of the quarantine.

“Through close collaboration among federal, state, and local partners, HHS helped protect the American people, contain potential risks, and bring this response effort to a successful conclusion,” HHS spokesperson Emily Hilliard said in an email.

More than 120 people were evacuated from the MV Hondius in Spain’s Canary Islands early last month — including the 18 Americans who wound up in the National Quarantine Unit in Omaha — though most were from other countries.

In addition to those people evacuated by health officials in full protective suits, at least 30 other passengers had left the ship earlier before the outbreak was documented. That included seven Americans, who were allowed to monitor for any symptoms at home. When the ship eventually docked in the Netherlands, 25 crew members and two medical personnel were on board and had to quarantine.

The World Health Organization didn't immediately respond Monday to questions about the status of all the other people who had to quarantine around the globe. A total of 13 cases of the virus, including the three who died, were identified among people who were on the ship.

One of the American passengers, Angela Perryman, had been held against her will and against the recommendation of a government medical expert. She said in an interview Monday passengers were told that the quarantine monitoring period ended Sunday at 2pm. She left on a flight that evening. Others were flying out Monday, she said.

“We were locked in our rooms until 1:55. And at 2 o’clock, ‘OK, well, everybody walk out and go home,’” Perryman said, speaking from her Florida home.

Some stayed the night elsewhere in Omaha, but Perryman pushed for a flight home that evening. The government paid for the flights, she said.

Seven of the last remaining patients remained there voluntarily, but Perryman was forced to stay as the result of a controversial quarantine order that was deemed unnecessary even by some health officials.

Perryman and seven others spent six weeks at the National Quarantine Unit at the University of Nebraska Medical Center. That monitoring period was set because symptoms of hantavirus have taken as long as 42 days to appear in previous outbreaks. None were reported to have develop the illness. The seven remained there voluntarily, but Perryman was forced to stay as the result of the controversial quarantine order.

Ten others who were at the facility were allowed to leave earlier under an agreement that they would be closely monitored in their home states.

The passengers were on a Dutch cruise ship, the MV Hondius, traveling in the South Atlantic that became the setting of a hantavirus outbreak that killed three people, including a Dutch couple who health officials believe were the first exposed to the virus while visiting South America.

Hantaviruses usually spread when people inhale contaminated residue of rodent droppings, but the hantavirus that caused the outbreak, called the Andes virus, may be able to spread between people in rare cases, health officials say.

Some 25 Americans were on the ship, including about seven who disembarked in April and 18 who remained on board. Sixteen were evacuated to the Nebraska quarantine unit in Omaha on May 11, and two other Americans joined them a few days later.

During the passengers’ stay, local Omaha restaurants and food trucks delivered special meals for them to enjoy almost daily. And the nurses sometimes made Starbucks runs to deliver some of the passengers’ favorite drinks.

The rooms they stayed in are like hotel rooms equipped with a desk, television, internet connection and exercise equipment to help the passengers pass the time.

One of the passengers, Jake Rosmarin, on Monday morning posted an "I’m finally coming home" video that showed him leaving his room at the quarantine center, hauling two suitcases and a backpack and turning out the lights as he walked out the door. Later Monday, he posted a video of the Omaha skyline shot out the window of his plane as he headed home to his fiance in Boston and his family.

Rosmarin, who is a travel blogger, posted a tearful video Sunday thanking the staff of the quarantine unit, the Omaha community and his family and friends who helped him get through quarantine.

“I want to thank the Omaha, Nebraska, community for welcoming us with open arms and showing us complete kindness and generosity. And a big thanks to all of you who have helped me get through this because I really don’t know if it would have been as easy without the support from strangers,” he said while wearing a Nebraska Huskers sweatshirt that someone sent him.

Perryman had a darker take. She was forced to stay after Florida officials refused a federal demand that the state provide round-the-clock surveillance on her if she were returned home. This even as they had started making travel arrangements for the passengers weeks ago, she said.

“Nobody actually expected anybody to get sick at that point,” she said. “Everybody was well aware that we were all going home on commercial flights.”

She called the six-week quarantine “a political stunt.”