AWS HealthOmics now supports Nextflow profiles, enabling customers to activate predefined execution settings at run time. Nextflow profiles allow customers to define reusable settings and select them at the point of execution, making it easy to switch between execution settings without modifying workflow source code. AWS HealthOmics is a HIPAA-eligible service that helps healthcare and life sciences customers accelerate scientific breakthroughs at scale with fully managed bioinformatics workflows.

With Nextflow profiles, you can cleanly separate platform-specific settings such as resource limits or execution options from core workflow logic. You can switch between development and production settings without creating separate workflow definitions. This reduces errors from manual edits, accelerates workflow portability, and saves time when scaling from development to production. If you use nf-core workflows, you can now activate the built-in and institutional profiles those pipelines already ship with.

You can now specify one or more Nextflow profiles in your workflow runs in all AWS HealthOmics Regions: US East (N. Virginia), US West (Oregon), Europe (Frankfurt, Ireland, London), Israel (Tel Aviv), and Asia Pacific (Singapore, Seoul). To learn more, visit the Nextflow Profiles section on HealthOmics Nextflow engine settings documentation.