Proterozoic metamorphism and deformation of the southern margin of the Superior craton in the Lake Superior region is attributed to the Penokean orogeny (1890−1830 Ma). This model includes a period of crustal inversion in which Archean basement blocks were exhumed through overlying Paleoproterozoic strata, producing the corridor of gneiss domes that parallels the trend of the Penokean orogen across the northern Midcontinent, USA. However, recent geologic mapping and ⁴⁰Ar/³⁹Ar geochronology challenge this interpretation, suggesting instead that the gneiss dome structures reflect younger episodes of tectonic activity along the southern margin of Laurentia. In absence of integrated pressure-temperature-time-deformation constraints for these rocks, interpretations are largely limited to their final cooling history, making it difficult to both identify the tectonic forces that shaped the architecture of the Penokean orogenic belt and assess the extent to which later Proterozoic tectonism modified the southern Superior craton. We address this problem with an approach joining thermodynamic modeling, garnet and accessory mineral geochronology, and microstructural analysis for several metamorphic rocks across the gneiss dome corridor. The U-Pb ages of titanite reveal that the Proterozoic geometries of exhumed basement gneiss domes are governed by preexisting Archean structures. Garnet Lu-Hf geochronology constrains the timing of prograde-to-peak metamorphism in the Penokean orogenic belt. Granulite facies metamorphism is related to the final stages of the Penokean orogeny at 1837 Ma and localized in a belt of high-grade rocks near a major Penokean suture. Garnet Lu-Hf ages of samples adjacent to gneiss domes reflect regional metamorphism following the accretionary phase of the Penokean orogeny, between 1825 Ma and 1782 Ma, which we suggest reflects continued crustal thickening related to convergence farther south during this time interval. Combination of garnet microstructures and Sm-Nd ages reflects later exhumation of gneiss domes and buried metasedimentary rocks by ca. 1750 Ma, consistent with previously published ⁴⁰Ar/³⁹Ar cooling ages across the region. Reset Lu-Hf and Sm-Nd garnet ages and U-Pb ages of syn-kinematic titanite reflect reactivation of primary Penokean structures during this period of basement uplift. These data document significant modification of the Penokean orogen and the Archean crust of the southern Superior province between 1800 Ma and 1700 Ma. Tectonic activity during this interval coincides with collisional events recognized in western Laurentia, suggesting that the period immediately following the Penokean orogeny may be a broadly important time for crustal growth and modification in proto-North America.