Luca Issi
RBC Capital Markets, Research Division

Capital Market. Today is a great privilege to have Beam as part of our 2026 Global Healthcare Conference. Representing the company, we have John Evans, Chief Executive Officer. John, thanks so much for joining us. How are you doing today?

John Evans
CEO & Director

Doing very well. Thank you, Luca.

Luca Issi
RBC Capital Markets, Research Division

Great. Long list of questions here, but maybe before we go into specifics, it would be great if you can maybe start a little bit big picture about what progress has the organization made recently and kind of what's ahead here for Beam?

John Evans
CEO & Director

Great. Yes. So it's great to see you all. So Beam Therapeutics is a next-generation gene editing company. We're working on a new form of CRISPR called base editing. And so this allows us to make single letter changes in genes on a permanent basis without needing to make a double-stranded break. This lets us make many more kinds of edits, more therapeutic edits, more precise edits, including doing things like correcting mutations back to normal rather than just knocking things out. We are pursuing this in a variety of different places, ex vivo and in hematology for the treatment of sickle cell disease. Our lead program, Risto-cel, is moving towards market, and we'll talk a little bit about that. I'm sure we'll have a BLA filing as soon as the end of this year, followed by a research effort to move sickle cure in vivo using some of our LNP capabilities.