Summary

• Longevity, the length of human life, is the subject of growing scientific and commercial interest.
• Functional performance metrics, molecular biomarkers, multiomics data, and continuous digital signals now can measure what clinicians once inferred almost entirely from chronological age.
• Our modeling suggests that premature death in the US claims 46 million life-years each year - worth roughly $4.6 trillion at standard health-economics valuations.
• As more people live longer, the composition of mortality is shifting. In younger cohorts, accidents and perinatal or congenital conditions account for the majority of fatalities.
• Advances in molecular biology and computation have shifted the measurement of aging further upstream, closer to the biological processes themselves.

By Shea Wihlborg, PhD, Research Analyst, Multiomics

Introduction

Longevity - the length of human life - is the subject of growing scientific and commercial interest. Often associated with “anti-aging,” the word carries connotations of cosmetic products, speculative therapies, and unproven claims. In our view, this association

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