Prince William has issued a brutal prediction on the marriage of his estranged brother Harry and sister-in-law Meghan Markle.

The Radar Online, citing the royal insiders, has reported that William has become increasingly convinced Harry and Meghan's marriage will eventually collapse.

The sources further told the outlet, that the Prince of Wales believes Meghan is responsible for the bitter royal rupture that has consumed the family for years.

A source close to the Prince of Wales has claimed William no longer believes reconciliation with Harry is possible while Meghan remains central to his life.

The insider said, "There's a public perception that William has completely turned against Harry and wants nothing more to do with him, but people close to the situation insist that isn't really the case.

"Deep down, William still sees Harry as his little brother and someone he once had an incredibly close bond with. The real resentment, in his mind, is directed toward Meghan because he believes the family dynamic dramatically changed after she entered the picture."

About the Prince of Wales predictions about Meghan and Harry’s future, the insider said, "If William believed he could still reach Harry without outside influence or distrust getting in the way, he probably would try. But at this point, he feels the damage is too serious, so he's taken the attitude that all he can really do is step back and wait to see how things unfold.

“Essentially, he has issued a pretty brutal prediction that Harry and Meghan's marriage has no hope of lasting."