Willis spent 10 years with Zappa, famously voicing the titular protagonist on the musician's three-disc rock opera, Joe's Garage

Ike Willis, the singer and guitarist who spent a decade with Frank Zappa and starred on his three-disc rock opera Joe’s Garage, died on Saturday, May 16, his family confirmed to Rolling Stone. He was 70.

A cause of death was not immediately available. In a 2022 JamBase interview, Willis revealed that he’d been diagnosed with prostate cancer.

In a statement, Willis’ family said they were “deeply heartbroken” to share the news of Willis’ death. He died in North Las Vegas “among loved ones.”

The statement continued: “Ike was not only a great father, but a musician whose unmistakable voice, humor, and artistry left a lasting imprint on the music world. His years of collaboration with Frank Zappa made him a cherished figure within the Zappa community, where fans embraced him not only for his talent, but for his generosity, wit, and the joy he brought to every stage. Beyond his work with Zappa, Ike continued to inspire new generations of musicians. His time mentoring young artists — including his stint teaching at School of Rock — reflected his deep belief that music should be shared, taught, and passed forward with love.

“At home, he was simply Dad: full of fun, warmth, and endless laughter over old Looney Tunes cartoons. He taught us beautiful customs and how to speak in the accents and languages of some of the people from wonderful cultural places he visited and performed at, around the world, giving us a glimpse into his travels. And he loved his original, old‑school Lakers with all his heart. These are the memories that will stay with us forever.”

The family ended by expressing their gratitude for “the outpouring of love from fans and friends around the world. As we continue to gather final details and navigate this profound loss, we ask for patience and privacy. Thank you for honoring his life, his music, and his legacy.”

Several of Willis’ fellow Zappa alums penned tributes, including drummers Vinnie Colaiuta and Chad Wackerman. “Ike was so much fun to be around,” Wackerman wrote of Willis on Facebook. “His ability to be creative and humorous gave Frank so much joy on stage. He was a talented guitarist but more than that he was one of the most incredible singers I have the honor to work with. Some nights on stage his singing would give me chills.”

Willis was a Zappa regular for nearly a decade, joining the group in 1978 and playing and recording with them through the end of Zappa’s final tour in 1988. Along with Joe’s Garage, he appeared on albums like Tinsel Town Rebellion, The Man From Utopia, Shut Up ‘n Play Yer Guitar, and another enormous triple-disc endeavor, Thing-Fish. Willis also contributed vocals and guitar to several live albums, including the You Can’t Do That on Stage Anymore series.

Willis was born and raised in St. Louis and started playing guitar as a kid. He met Zappa when he was a college student, working as a member of the in-house concert tech crew at Washington University in St. Louis. When Zappa played a show at the school, Willis got to meet him backstage. Zappa asked if Willis knew any of his own songs and, thanks to a friend, he did. Zappa was so impressed with Willis’ playing, he invited the young musician to officially audition after his graduation.

Willis’ first major project with Zappa was Joe’s Garage, an ambitious rock opera that dealt with many of Zappa’s favorite themes, including free speech, censorship, zany sex, love, religion, the evils of the music industry, and authoritarian rule. Zappa tasked Willis with voicing the rock opera’s eponymous protagonist, Joe, who goes on a journey from normal teenager with a garage band, to devotee of “L. Ron Hoover’s Church of Appliantology,” to an inmate who spends his prison term imagining guitar solos, to an ex-con trying to survive in a world where music has been outlawed. 

In a 2018 interview, Willis said Zappa had great “confidence” in him, and recalled what made him stand out to the bandleader: “He finally told me one day, when we were recording Joe’s Garage, the main thing he liked about me was the fact that I did the one thing that no other band member was able to do, which was essentially, follow directions … I had the easiest job on Earth and all I had to do was do what the boss said!”

Willis was a rare constant in a Zappa universe where musicians were often coming and going. He was deeply loyal to Zappa, and Zappa appreciated not only Willis’ sense of humor but his encyclopedic knowledge of music.

Outside of Zappa, Willis had his own group, the Ike Willis Band, which released a debut album, Should’a Gone Before I Left, in 1987. They released a second record, Dirty Pictures, in 1998. After Zappa died in 1993, Willis frequently toured with his own group, but also remained deeply involved with various Zappa tribute efforts. 

“The fact that I am still doing this — I am doing it for them, and for Frank,” Willis told JamBase of the late musician and his devoted fans. “It was a privilege for me to be able to perform and to be a part of this person’s orbit.”