Welcome to the age of bioacceleration: of Chinese peptide raves, longevity for dogs, icing your ballsack in the sauna, and CRISPRing your kids. Of diet pills for men and creatine for women; of the pharma, cosmetics, and biotech industries merging into one. Elizabeth Holmes is on her Twitter redemption arc and at-home blood tests are back in. If 2025 was defined by the San Francisco AI boom, I won’t be surprised to see consumer biotech—from designer babies to peptide pill mills—take off in 2026.
Last September, I wrote about how the tech community is embracing “agency” and “taste” as a hedge against AGI. But it requires nontrivial effort to buy art or read Middlemarch or come up with an idea for a billion-dollar app to Claude Code. And Opus 9.9 (new) is probably just around the corner, ready to come up with better takes than we could dream of ourselves. So—it seems like we won’t be outcompeting the machines on the cognitive frontier. What if we applied all this intelligence to get really, really hot?
Recently, people from right-wing Twitter anons to the hosts of Odd Lots have embraced “looksmaxxing” as the most robust human defense against machines who are smarter and faster workers than we are. Others, like Bryan Johnson, are interested in not-dying as a way to survive the transition to superintelligence. Then there are the normal reasons to care about health: sickness and death are some of the most arbitrary and unfair things that happen to people, and we should try as hard as we can to prevent them.
Whatever the cause, I’ve noticed a spike in body-talk in Silicon Valley. No longer do technologists view themselves as mere brains in jars, but as embodied flesh-and-blood beings with all the pleasures and vulnerabilities that entails. So here’s a quick tour through some of the more mystifying health and bio terms I’ve seen:
In the last few years, “autistic” went from a very un-PC insult for a socially awkward person to a badge of honor among technologists. Founders talk about feigning autism for VC meetings, being “autistically focused” instead of merely “obsessed.” Like the millennials who called themselves sooo OCD for correcting everyone’s grammar, SF is experiencing an epidemic of tizz inflation and I need Jerome Powell to stop it.1
I assume this shift reflects the particular culture of the AI boom. At Google and Facebook circa 2010, growth PMs ruled the roost—the equivalent of fratty finance guys with their beer kegs and bloviating. But at today’s frontier AI companies, recovering physics PhDs, burned-out quants, and logorrheic LessWrong vets top the status ladder. The labs’ success so far has relied on raw technical talent—on research breakthroughs rather than growth hacks.
Last year, Kevin Roose and I interviewed legions of such researchers for his forthcoming book. They tend to be earnest and delightfully nerdy; they also tend to be god-awful storytellers for narrative journalists like us. At least five times, the question “Can you tell a story to show X?” returned the reply “Sorry, my brain doesn’t index things that way.”
roon@tszzl
all the people that can make eye contact at openai joined in the last 6 months and they’re making me uncomfortable with their eye contact
7:07 PM · Oct 17, 2023 · 1M Views
144 Replies · 155 Reposts · 4.8K Likes
But we might be at peak autism now, and the tech ecosystem knows it. Two macro factors to note: first, LLMs are moving from the research/scaling era to the applications/diffusion era, where productization and sales will make a bigger difference. Second, LLMs themselves are sort of stereotypically autistic, equipped with savant-like memories and little common sense to speak of. Humanity’s edge over machines will come from embracing EQ as much as IQ.
Thus, per my 2026 ins and outs list, I predict that tizz is out and rizz is in.
conor brennan-burke@conor_ai
the tizz / rizz founder matrix (TRFM) all great founders land somewhere on here tag yourself cooked up with @jia_seed
3:54 PM · Aug 28, 2025 · 567K Views
199 Replies · 229 Reposts · 4.04K Likes
Related terms: the ‘tizz, rizz, eye contact
“If you’re not maxxing, you’re minning.”
— anonymous AI founder and peptide enthusiast
Want to camouflage your autism? Try Chinese peptides.
will depue@willdepue
i may have started something in sf with recommending nasal oxytocin. this will be ozempic for autism. one day you won’t know why but all the ML researchers at the rock climbing gym will be capable of intense eye contact.
9:12 PM · Mar 27, 2025 · 34.6K Views
21 Replies · 11 Reposts · 456 Likes
Props to whoever came up with “Chinese peptides” because it’s one of the most mimetic concepts of 2025.2 It blends Bay Area biohacking and Gen Z looks-maxxing; it’s a way to say “screw the FDA” while hitting your gym KPIs. Chinese peptides were the subject of my first New York Times piece and Odd Lots appearance: a vivid encapsulation of SF’s frontier ethos, a community that prides itself on taking the risks—and reaping the rewards—that most people won’t.3
Peptides are a broad chemical category. They describe any short chain of amino acids, and technically include everything from insulin to GLP-1s to a slew of unapproved “research chemicals” that promise to make you hotter, smarter, buffer, and cooler. But when people say they’re “into peptides” it’s usually less “I have type 1 diabetes” and more “I’m WeChatting Qingdao Sigma Chemical Co. to buy mysterious powders to inject myself with.” One user compared the reconstitution process to a high school chemistry lab.
So why the boom, and why now? It started with GLP-1s, which are both a feat of modern medicine and made needle play way less scary to the masses. Tack on a Silicon Valley worldview that dreams of a quick fix for every ill and China’s low-cost manufacturing prowess: the result is an explosion in gray-market peptides borrowing off Ozempic’s aura.
There’s also a whole guerrilla epistemology that accompanies peptide use, which I have to assume is part of the fun. Rather than doctors, people are getting peptide tips from friends, Reddit, and ChatGPT. There are Telegram groups with channels like “Growth Hormone Secretagogues” (where people share dosing for BPC-157 and TB-500), “Write to Bryan Johnson” (a joking intro message from Bryan: “Here to find blood boys 🩸”), and Ageless Dating (one bio reads “I am 41, but my biological age is 32”). And I’ve observed in real time how talking peptides at a house party has a natural virality—say the word, and you’ll soon find yourself in a flock of intrigued partygoers, all sharing their stacks, dealers, and asking how to get in on the craze.4
Related terms: GLP-3s, peptide rave, ozempic face
“Julius Caesar: natty or not?”
— overheard at a SF house party
We’re in a nationwide panic over the fate of young men: goon caves, gambling addictions, 4chan groyper radicalization. Everywhere you look, The Boys Are Not OK, and the same goes for the many men of Silicon Valley.
Bryan Johnson@bryan_johnson
men, 2026 is the time to get our shit together. the modern world has made human slop of us. fertility rates are down 62%. metabolic disease afflicts 35%. obesity has hit 40%. 63% are not having sex weekly. testosterone is dropping 1% every year. 42% over forty have erectile
5:55 PM · Dec 31, 2025 · 622K Views
372 Replies · 1.21K Reposts · 13.6K Likes
What is to be done about the so-called masculinity crisis? For the scientifically minded, one approach is to target the biological essence of masculinity itself: testosterone, or T, the hormone linked to aggression, risk-taking, libido, fertility, and energy. We know that sperm counts and T-levels have fallen nationwide. So dig into the causes there—maybe obesity, pollution, the “feminization” of our culture and vibes.
There were a few months when the men in my life became exceptionally concerned about plastic chemicals, which have been linked to lower T-levels due to endocrine disruption. “I’m not touching that receipt,” said a friend after a grocery run, contorting his face into a grimace. “I gotta switch to Spindrift,” mourned a coworker, realizing it was the only seltzer in our fridge with less than 1ppt of PFAS. They weighed the risk-reward of drinking Fairlife (more protein, more phthalates) and religiously referenced Github founder Nat Friedman’s PlasticList. I mean, I get it. Plastic shards in your balls—what could be worse than that?
Amjad Masad@amasad
Whole Plastics: “nice testosterone you got there, be shame if something were to happen to it”
8:10 PM · Dec 28, 2024 · 132K Views
52 Replies · 29 Reposts · 705 Likes
Historically, trans men were among the first biohackers, self-injecting T to grow beards and deepen voices since the 1930s. Today, T-boosting tactics have hit the cis mainstream too. There are inter-lab lifting competitions, televised sperm races, “detwinkification” challenges where young engineers compete to gain muscle mass. Bryan Johnson tweets regular updates on his testosterone levels. Even high-powered women are experimenting with exogenous T.
Not all these activities have the explicit goal of raising T, but the industry feels more boyish than ever, and high-T is a style as much as a biomarker. In my favorite since-deleted phrase from the hit book Breakneck, Dan Wang declared that the US’s “failure to build enough has hurt working people and makes the country feel like a low-agency, low-T society.” To be a founder, a builder, a pioneer—these are the masculine traits we need to bring America back.
Related terms: sperm counts, fertility crisis
“if you’re so smart why aren’t you hot”
— @creatine_cycle, niche san francisco technology culture podcaster
“Physiognomy” used to be a word I only saw on Race Science Twitter, but unfortunately, this is all of Twitter now. The term refers to the practice—originated by Aristotle, detailed by 20th century racists, and revived by modern-day X anons—of inferring a person’s character from their appearance.
Physiognomy promises a simple moral cheat code: ugly = bad, hot = good, middle-aged white woman = evil HR Karen. “Fat” is back in vogue as an insult again; the Trump admin loves to deploy it, but the left is guilty too.5
I wonder how much these macrocultural trends have influenced Zuckerberg’s and Bezos’s recent glow-ups. You might think that transitioning into being an elder statesman of Silicon Valley might involve a renewed sense of noblesse oblige, but for those two, it’s more like getting jacked, a wardrobe reset, and taking any opportunity to flex with your wife.
Physiognomy, however, may contain the seeds of its own destruction. It was popularized as a pseudoscientific way to predict individuals’ futures—they thought a prominent browbone suggested criminality, for instance—but in a world where cosmetic enhancement is more advanced and common than ever, how we look increasingly reflects our choices, culture, and wealth more than our genes.
Related terms: phrenology, ethnoguessr, clavicular, looksmaxxing
“I want to live in a world where when people get drunk, instead of getting tattoos, they CRISPR themselves.”
— Josie Zayner, PhD, at the Substack Utopia Debate
Nothing terrifies rich, neurotic parents more than the prospect of birthing a child who isn’t as successful as they are.
Since freshman year of college, my Instagram has been inundated by ads promising anywhere from $30k to $300k to donate my eggs. The posts are filled with stock images of radiantly smiling women and language hinting at how broke you are. The requirements—commonly an elite education (Yale, Harvard, Stanford, MIT, Tsinghua, Peking), 20-30 years old, over 5’5”, a healthy family history—read somewhere between a job listing and a medical report. Though for the intended parents, I suppose it makes sense: “bio-mother” is the highest-stakes hire they’ll ever make.
But ensuring your eggs are triple-A organic is only step one. Many Silicon Valley parents are additionally opting for embryo-screening services like Orchid Health and Nucleus Genomics to avoid genetic diseases or even maximize height and intelligence. Then there are the things you can do for your kids after birth. Never mind SAT prep and trust funds—some rich parents are giving their teen boys HGH to help them grow taller.
Deedy@deedydas
Being short as a man is a huge handicap. Few know that wealthy parents give their boys naturally secreted human growth hormone ($30-50/mg for Omnitrope/Genotropin), 0.16-0.24mg/kg from age 11-16. For $100k-200k, you add 5 inches to projected height in 7yrs! You can BUY height.
2:44 AM · Sep 21, 2024 · 1.54M Views
302 Replies · 314 Reposts · 5.38K Likes
Coming soon are wilder efforts to directly gene-edit embryos (currently illegal in the US). Social norms are the only barrier standing between us and human genetic engineering; given how regulatory entrepreneurship conquered taxi, hotel, and securities laws, you bet some brazen founders think they can beat these too. As startups are wont to do with sci-fi plots, GATTACA has served as more an inspiration than a warning.
Related terms: D1 babies, He Jiankui, surrogacy, GATTACA
“Sex is for fun, and embryo screening is for babies.”
— Noor Siddiqui, founder of Orchid Health
All around the world, fertility rates have fallen off a cliff. Try as policymakers might, their constituents just aren’t having more kids. Baby bonuses don’t do much. Propaganda campaigns don’t do much. In South Korea, home to the lowest fertility rates in the world, some have resigned themselves to the idea that in a century or so, the country will simply… go extinct.
The concern makes sense: no children, no future. As such, progress studies organizations—generally more econ nerds than social theorists—have taken up pronatalism as a pet issue. Sure, TFR charts aren’t a very sexy way to talk about the beauty and joy of family-making. (Leave it to the wonks to make getting cuffed an economic mandate.) But perhaps it really is worth considering if there’s a technological salve: Do we need in vitro maturation? Robot nannies? What about artificial wombs? Or Einstein clones?
Amanda Askell@AmandaAskell
It's bizarre when relatively techno-utopian people are asked about how to solve declining fertility and instead of talking about artificial wombs, extended fertility spans, AI-assisted childcare, UBI, etc. they're suddenly like "well we just need to return to the 50s".
4:30 PM · Mar 19, 2025 · 128K Views
169 Replies · 146 Reposts · 1.99K Likes
Meanwhile, a few tech moguls have taken the global fertility crisis into their own hands—and penises. Elon Musk and Telegram founder Pavel Durov are notorious for paying women to have kids using their sperm. What’s remarkable are the existential stakes they use to frame their hobby: a “civic duty” for Durov, a means of preserving Western civilization for Musk. “Low birth rate is the number one threat to the West, followed closely by migration,” Musk tweeted in September; thus it is the rich white man’s burden to spread his high-IQ seed.6 And being a billionaire playboy the normal way (having sex with lots of women) is apparently still too much effort, so why not speedrun the process via IVF?
This makes for an odd cacophony of reproductive trends. I can’t imagine that the same anxious optimization culture that drives tech leaders toward rigid health regimens and careful embryo selection is especially encouraging of having more kids. And I am suspicious of top-down efforts to facilitate childbearing, which in practice often look like pressuring women to stay in bad marriages, leave the workforce, and assume the vast majority of childcare duty. (I’ve noticed in my own circles a disparity between the number of eager young men who want 4+ kids versus the number of women excited to bear them.)
Of all the metrics to hack, other people’s kids are some of the most consequential. So if Silicon Valley takes on TFR decline, I hope the solutions focus on enabling people to have more of the families they want.
Related terms: pronatalist, Genghis Khan, birth rates
The Bay Area has a deep-rooted interest in nootropics, longevity, genetics, and population science. It was on the same 1990s listserv that the Extropians coined the terms “AGI” and “immortalism”; in the same 2012 book that Nick Bostrom sketched out machine superintelligence and human clones. When I reread a 1994 WIRED profile of the Extropians, I was surprised at how contemporary their aspirations seem:
No longer is biology destiny: with genetic engineering, biology is under human control. And with nanotechnology, smart drugs, and advances in computation and artificial intelligence, so is human psychology. Suddenly technology has given us powers with which we can manipulate not only external reality - the physical world - but also, and much more portentously, ourselves. We can become whatever we want to be: that is the core of the Extropian dream.
If anything, what the Extropians underestimated is how popular their project would be. There’s infinite demand for getting hotter and healthier, and in the wake of a trust crisis in public health—fueled by Covid controversies and exorbitant costs—people everywhere are more eager than ever to try unconventional paths to get there.
Twice last year, I mentioned struggling with focus, only for an acquaintance to disappear and return with loose Adderall to dump in my palm. “You have to try this,” they’d say, before launching into a heap of dosing instructions. (Stimulant prescriptions jumped roughly 20% from 2019 to 2023, largely due to telehealth providers.) I wrote the Chinese peptides story after realizing it wasn’t just a meme—multiple people I knew were on them, mostly to lose weight. (Gray-market peptide and hormone imports from China doubled to over $328 million in 2025.) The genetics stuff seems out-there for now, but I anticipate those barriers too falling with cost and UX.
This is to say nothing of nicotine, creatine, melatonin, modafinil, and psychedelic therapy; of plastic surgery, lip fillers, Botox, red light, and Korean skincare routines. Tabloids scrutinize pop stars to backwards-engineer their cosmetic enhancements; productivity-maxxing YouTubers show viewers how to replicate billionaire morning routines. We all know that rich people are buying wellness with stuff much stronger than what’s at CVS. The only question is: don’t gatekeep, how can I do it too?
Mass adoption will be driven by an arms race dynamic. If you don’t take the pills, you might fall behind. “Nearly one in four American adults is currently modifying their biology or morphology via significant pharmaceutical or surgical intervention,” estimates Ben Goldhaber. “There’s too much latent demand for suprahuman living for the current equilibrium to hold. At some point it becomes common knowledge that no one’s natty anymore.”
The Chinese peptides story was my first for the NYT. Thanks especially to Noreen Malone at the NYT for her patient edits and support.
It’s not often you get a story about biohacking and pharma regulation and China competition and supply chains and SF culture, all at the same time. There are so many rabbit holes to go down, and I’m excited to do more bio/health coverage now.
People are really interested in the peptides. It came out 2 hours before the bombs on Venezuela, but fortunately wasn’t totally buried—it got some nice print real estate and above-average web traffic. In addition to a bunch of podcasts, I even went on cable news!
I’m pretty horrified by ICE’s escalating brutality, from the murder of Renee Nicole Good in Minneapolis to countless others, U.S. citizens and noncitizens alike. It’s hard to know what to do, but:
I’m donating to organizations that provide direct legal services to immigrants targeted by ICE. You might consider RAICES (Texas/national), Centro Legal de la Raza (Bay Area), or NILC (national/litigation-focused).
For tech workers, I’ve been forwarded this petition you can sign to ask your leadership to keep ICE out of cities and cancel ICE contracts.
Some fun job postings! Knowing who’s involved, I expect these roles to be as entrepreneurial as media roles get. Do mention my name if you end up interviewing for any.
Editor for the think tank IFP, where you’ll help write Substacks and policy memos and work with Santi Ruiz.
Podcast editor for Odd Lots, where you’ll become a true polymath and discoverer of Perfect Guests™.
Stay healthy & hot & safe out there —
Jasmine