Information theory is a powerful framework to capture aspects of dynamical systems with multiple degrees of freedom. Mathematically, the dynamics can be represented as a continuous curve $\mathcal{C}$ on a suitable hyperplane in flat space and the Fisher information provides the norm of an infinitesimal displacement along this curve. In many applications, however, we do not have direct access to $\mathcal{C}$. Instead, we have to reconstruct the latter from a time-series of measurements (obtained as samples of size $n$), which are represented by an ordered set of points $\widehat{\mathcal{C}}$ on the same hyperplane. In this work, we calculate the bias of the Fisher information for large $n$, which provides a quantitative estimation for how accurately the dynamics of a system can be reconstructed from a given set of sampled data. Based on this result, we show that a clustering of the degrees of freedom reduces the bias and thus improves the accuracy with which the new system can be described with the same data. Inspired by a recent proposal for such a clustering, we provide a quantitive assessment of the loss of information, which allows to estimate how much information about the dynamics of a system can reliably be extracted based on a given set of data. We illustrate our findings in the case of a simple compartmental model. Although the latter is inspired by epidemiology, the results of this work are applicable to very general dynamical models with multiple degrees of freedom.