Network densification along with universal resources reuse is expected to play a key role in the realization of 5G radio access as an enabler for delivering most of the anticipated network capacity improvements. On the one hand, neither the expected additional spectrum allocation nor the forthcoming novel air-interface processing techniques will be sufficient for sustaining the anticipated exponentially-increasing mobile data traffic. On the other hand, enhanced ultra-dense infrastructure deployments are expected to provide remarkable capacity gains, regardless of the evolutionary or revolutionary approach followed towards 5G development. In this work, we thoroughly examine global network coordination as the main enabler for future 5G large dense small-cell deployments. We propose a powerful radio resources coordination framework through which interference management is handled network-wise and jointly over multiple dimensions. In particular, we explore strategies for pairing serving and served access nodes, partitioning the available network resources, as well as dynamically allocating power per pair, towards optimizing system performance and guaranteeing individual minimum performance levels. We develop new optimization formulations, providing network scaling performance upper bounds, along with lower complexity algorithmic solutions tailored to large networks. We apply the proposed solutions to dense network deployments, in order to obtain useful insights on network performance and optimization, such as rate scaling, infrastructure density, optimal bandwidth partitioning and spatial reuse factor optimization.