In this paper, a novel blind multi-user detection(MUD) framework for autonomous grant-free high-overloading non-orthogonal multiple access is introduced in detail aimed at fulfilling the requirements of fifth-generation massive Machine Type Communications. From the perspective of the transmitter side, pros and cons regarding diverse types of emerging grant-free transmission, particularly autonomous grant-free, are elaborated and presented in a comparative manner. In the receiver end,code word-level successive interference cancellation (CL-SIC) is revealed as the main framework to perform MUD. In addition, underpinning state-of-art blind ideas such as blind activation detection taking advantage of the statistical metric of the aggregate signals, blind equalization based on the constellation's simple geometric character of low order modulation symbols, and blind channel estimation employing solely the successfully decoded code words are explained.