There are no universally accepted definitions of Rényi conditional entropy and Rényi mutual information, although motivated by different applications, several definitions have been proposed in the literature. In this paper, we consider a family of two-parameter Rényi conditional entropy and a family of two-parameter Rényi mutual information. By performing a change of variables for the parameters, the two-parameter Rényi conditional entropy we study coincides precisely with the definition introduced by Hayashi and Tan [IEEE Trans. Inf. Theory, 2016], and it also emerges naturally as the classical specialization of the three-parameter quantum Rényi conditional entropy recently put forward by Rubboli, Goodarzi, and Tomamichel [arXiv:2410.21976 (2024)]. We establish several fundamental properties of the two-parameter Rényi conditional entropy, including monotonicity with respect to the parameters and variational expression. The associated two-parameter Rényi mutual information considered in this paper is new and it unifies three commonly used variants of Rényi mutual information. For this quantity, we prove several important properties, including the non-negativity, additivity, data processing inequality, monotonicity with respect to the parameters, variational expression, as well as convexity and concavity. Finally, we demonstrate that these two-parameter Rényi information quantities can be used to characterize the strong converse exponents in privacy amplification and soft covering problems under Rényi divergence of order $α\in (0, \infty)$.