The principle of orthogonal time-frequency-space (OTFS) signaling is firstly analyzed, followed by explaining that OTFS embeds another signaling scheme referred to as orthogonal short-time Fourier (OSTF). Then, the relationship among OTFS, OSTF, orthogonal frequency-division multiplexing (OFDM) and single-carrier frequency-division multiple-access (SC-FDMA) is explored, demonstrating that OSTF/OTFS are fundamentally the extensions of OFDM/SC-FDMA from one-dimensional (1D) signaling to two-dimensional (2D) signaling. Hence, the characteristics and performance of OSTF/OTFS schemes can be perceived from the well-understood OFDM/SC-FDMA schemes. Accordingly, the advantages and disadvantages of OSTF/OTFS are discussed. Furthermore, from the principles of OFDM/SC-FDMA, the multiuser multiplexing in OSTF/OTFS systems is analyzed with respect to uplink and downlink, respectively. Added on this, a range of generalized multiplexing schemes are presented, whose characteristics are briefly analyzed.