A function from $\Bbb F_{2^n}$ to $\Bbb F_{2^n}$ is said to be {\em $k$th order sum-free} if the sum of its values over each $k$-dimensional $\Bbb F_2$-affine subspace of $\Bbb F_{2^n}$ is nonzero. This notion was recently introduced by C. Carlet as, among other things, a generalization of APN functions. At the center of this new topic is a conjecture about the sum-freedom of the multiplicative inverse function $f_{\text{\rm inv}}(x)=x^{-1}$ (with $0^{-1}$ defined to be $0$). It is known that $f_{\text{\rm inv}}$ is 2nd order (equivalently, $(n-2)$th order) sum-free if and only if $n$ is odd, and it is conjectured that for $3\le k\le n-3$, $f_{\text{\rm inv}}$ is never $k$th order sum-free. The conjecture has been confirmed for even $n$ but remains open for odd $n$. In the present paper, we show that the conjecture holds under each of the following conditions: (1) $n=13$; (2) $3\mid n$; (3) $5\mid n$; (4) the smallest prime divisor $l$ of $n$ satisfies $(l-1)(l+2)\le (n+1)/2$. We also determine the ``right'' $q$-ary generalization of the binary multiplicative inverse function $f_{\text{\rm inv}}$ in the context of sum-freedom. This $q$-ary generalization not only maintains most results for its binary version, but also exhibits some extraordinary phenomena that are not observed in the binary case.