In recent years, thanks to the advances in meta-materials, the concept of continuous-aperture MIMO (CAP-MIMO) is reinvestigated to achieve improved communication performance with limited antenna apertures. Unlike the classical MIMO composed of discrete antennas, CAP-MIMO has a quasi-continuous antenna surface, which is expected to generate any current distribution (i.e., pattern) and induce controllable spatial electromagnetic (EM) waves. In this way, the information is directly modulated on the EM waves, which makes it promising to approach the ultimate capacity of finite apertures. The pattern design is the key factor to determine the communication performance of CAP-MIMO, but it has not been well studied in the literature. In this paper, we develop pattern-division multiplexing (PDM) to design the patterns for CAP-MIMO. Specifically, we first study and model a typical multi-user CAP-MIMO system, which allows us to formulate the sum-rate maximization problem. Then, we develop a general PDM technique to transform the design of the continuous pattern functions to the design of their projection lengths on finite orthogonal bases, which can overcome the challenge of functional programming. Utilizing PDM, we further propose a block coordinate descent (BCD) based pattern design scheme to solve the formulated sum-rate maximization problem. Simulation results show that, the sum-rate achieved by the proposed scheme is higher than that achieved by benchmark schemes, which demonstrates the effectiveness of the developed PDM for CAP-MIMO.