Channel state information (CSI) has been a key component in traditional wireless communication systems. This might no longer hold in future networks supporting services with stringent quality of service constraints such as extremely low-latency, low-energy and/or large number of simultaneously connected devices, where acquiring CSI would become extremely costly or even impractical. We overview the main limitations of CSI at transmitter side (CSIT)-based designs toward the 6G era, assess how to design and use efficient CSIT-limited schemes that allow meeting the new and stringent requirements, and highlight some key research directions. We delve into the ideas of efficiently allocating pilot sequences, relying on statistical CSIT and/or using location-based strategies, and demonstrate viability via a selected use case.